Clarity For The Most Complex Genomic Regions

Benthic Genomics converts complex genomic regions into crisp, actionable, and high-confidence genomic calls – at higher precision and scale compared to standard microarray and NGS methods.

Critical health information hides in complex genomic regions

Complex genomic regions like HLA, KIR, and polymorphic pharmacogenes have the highest amount of disease associations and require specialized tools. The Benthic Analysis Platform converts your microarray and sequencing data into a precise, high-resolution view of these areas. This means deeper, more accurate insights without changing your lab workflow.

Adapted from Kennedy, A. E., et al. (2017). DOI: 10.1111/iji.12332

Benthic Genomics Takes 'Dark' Regions to High-Resolution Results

Our software platform is compatible with a wide range of genomic input types – from microarray to short-read and even long-read sequencing – giving you high-resolution genotyping and variant calls across dozens of hard to characterize immune genes.

For Microarrays:

Elevate your microarray data to a new performance tier. Our platform delivers accuracy and resolution that surpasses typical NGS – providing a seamless, high-performance drop-in solution that sidesteps the high costs and workflow complexities of sequencing.

Get NGS-Level Microarray Results

For Short-Read NGS:

Elevate your genomic analysis by obtaining fully phased, haplotype-level results directly from your standard short-read sequencing data. This approach provides superior variant calling and full structural information even in complex regions.

Resolve Haplotypes from Short Reads

For Long-Read Sequencing:

Achieve large-scale, ground-truth immunogenomics. Our long-read enrichment workflow generates complete, phased assemblies of complex loci like HLA and KIR, resolving haplotypes, structure, and allele specific methylation signatures.

Explore Our Long-Read Workflow

Connect With Us at Upcoming Conferences

Find out where we’ll be next and schedule time with us.

AAI IMMUNOLOGY2026™

📅 April 15-19, 2026

📍 Boston, MA

AACR Annual Meeting 2026

📅 April 19-22, 2026

📍 San Diego, CA

SFA²F Meeting 2026

📅 May 19-21, 2026

📍 Santa Fe, NM

Meet

Mako Analysis

™

for NGS

Superior Performance in Complex Regions from NGS Data

Mako combines capabilities that are typically split across multiple tools in one short-read workflow: phased haplotype reconstruction, high-resolution HLA typing, and comprehensive immune-region variant calling.

Download Mako Brochure

Mako Comparison To SR HLA Typing Tools.png

Phased MHC Haplotypes

Mako reconstructs haplotypes across the MHC, enabling fine-mapping, association studies, and clearer interpretation of immunogenomics.

High-Resolution HLA Typing

Mako delivers 4-field resolution HLA typing with extended coverage across 45 genes in the MHC.

High-Resolution
HLA Typing

SNPs & SVs
Across the MHC

SNPs & SVs Across the MHC

Mako goes beyond classical HLA genes to recover dense variant calls across the MHC, including immune genes such as MICA/B and TAP1/2.

Main Contact Form

Let’s Resolve Your Most Complex Genomic Regions

Get in touch to try our platform on your own microarray or NGS data.